Cytokines in non-genotoxic hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Cytokines in non-genotoxic hepatocarcinogenesis.
Many toxicants can cause liver injury. Some, such as diethylnitrosamine, are genotoxic and act principally by damaging DNA (1). A second more diverse group cause liver injury but are non-genotoxic (2). Despite differences in the primary target, genotoxic and non-genotoxic hepatotoxicants frequently cause tumours in the liver of experimental rats and mice (1,2). This review is concerned with eva...
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A range of hepatoma cell lines (RH1, HTC, FaO, 7800C1 and MH1C1), has been studied with the aim of establishing an in vitro model to investigate the molecular mechanisms of hepatocarcinogenicity induced by the peroxisome proliferator class of non-genotoxic carcinogens. In view of speculation that peroxisome proliferators suppress hepatocyte apoptosis in vivo, we have placed particular emphasis ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1999
ISSN: 1460-2180
DOI: 10.1093/carcin/20.8.1397